Investigator: Professor Robert Grimble Starting date: March 2003 Grants: LINK Award from the Biotechnology and Biological Sciences Research Council
This collaborative project is an intervention study involving 400 men, aimed
at studying the effects of vitamin E supplementation on early stage rheumatoid
arthritis. During the study, participants will be genotyped by Sciona, and
their biomarkers will be measured by the University of Southampton. This study
is related to an earlier investigation which showed a positive response to fish
oils in individuals with certain genotypes. The current investigation will further
explore the hypothesis concerning the existence of a pro-inflammatory genotype
that can be defined by studying individual variation in specific genes. Genes
to be evaluated include those related to inflammatory response as well as to
innate antioxidant activity.
